Our Focus
Analyze the Three-Dimensional Structure of α-Syn and Conduct Molecular Interaction Studies by Using Structural Biology Technology
Relying on the structural biology technology platform, SynuSight has accumulated rich experience in the research of α-Syn, and carries out structural analysis and mechanism research of different α-Syn mutants and compound complexes through a multi-dimensional research system.
Investigating the Binding Mode of Ligands to α-Syn Proteins
SynuSight has resolved the high-resolution structures of a variety of compounds with α-Syn fibers. The results show that small molecule ligands exhibit three distinct conformational relationships when binding to fibers: diagonal geometry, horizontal geometry, and vertical geometry. Compared with conventional protein-ligand interactions, these binding patterns reveal a key feature - the π-π stacking between small molecule ligands is decisive for their specificity in binding amyloid fibrils.
A New Paradigm of Structure-Driven Drug Design
Building upon profound structural biology insights, SynuSight has pioneered a novel "Structure-Driven Drug Design" paradigm. By integrating AI algorithms with computer-aided drug design (CADD) technologies, we have achieved de novo development of a next-generation tracer featuring a novel molecular scaffold. This compound demonstrates both high specificity for α-Syn binding and exceptional blood-brain barrier (BBB) penetration with validated imaging performance in clinical studies.
